Functional characteristics of non-NMDA-type ionotropic glutamate receptor channels in AII amacrine cells in rat retina.

@article{Mrkve2002FunctionalCO,
  title={Functional characteristics of non-NMDA-type ionotropic glutamate receptor channels in AII amacrine cells in rat retina.},
  author={Svein Harald M\orkve and Margaret Lin Veruki and Espen Hartveit},
  journal={The Journal of physiology},
  year={2002},
  volume={542 Pt 1},
  pages={147-65}
}
The properties of non-NMDA glutamate receptor channels in AII amacrine cells were studied by patch-clamp recording from rat retinal slices. Application of AMPA or kainate to intact cells evoked currents with no apparent desensitization (EC50 of 118 microM for AMPA and 169 microM for kainate). Application of AMPA to patches evoked desensitizing responses with an EC50 of 217 and 88 microM for the peak and steady-state responses, respectively. Kainate-evoked responses of patches displayed no… CONTINUE READING

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