Functional characteristics of cysteinyl-leukotriene receptor subtypes.

  title={Functional characteristics of cysteinyl-leukotriene receptor subtypes.},
  author={Magnus B{\"a}ck},
  journal={Life sciences},
  volume={71 6},
Cysteinyl-leukotrienes, i.e. leukotriene (LT) C4, D4 and E4, are inflammatory mediators and potent airway- and vasoconstrictors. Two different cysteinyl-leukotriene receptors, CysLT1 and CysLT2, have been cloned and functionally characterised using potent CysLT1 receptor antagonists and the dual CysLT1/CysLT2 receptor antagonist BAY u9773. However, the rank order of potency of the cysteinyl-leukotrienes at the CysLT receptors differs between tissues and studies, and a CysLT receptor… CONTINUE READING

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