Functional characteristics of cancer stem cells and their role in drug resistance of prostate cancer

@inproceedings{Castillo2014FunctionalCO,
  title={Functional characteristics of cancer stem cells and their role in drug resistance of prostate cancer},
  author={Viviana Castillo and Rodrigo Valenzuela and Christian Huidobro and H{\'e}ctor R. Contreras and Enrique A. Castell{\'o}n},
  booktitle={International journal of oncology},
  year={2014}
}
Cancer stem cells (CSCs) have the ability to self-renew and differentiate to give rise to heterogeneous phenotype of the tumor cells. It is believed that these cells are involved in metastasis, recurrence and therapy resistance in various cancers. CSCs have been identified in prostate cancer (PCa), one of the most diagnosed malignancies in men over the world, for which chemotherapy resistance is a major problem in the treatment of castration-resistant advanced stages. Molecular signatures, gene… CONTINUE READING
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