Functional characterisation of human TASK-3, an acid-sensitive two-pore domain potassium channel

  title={Functional characterisation of human TASK-3, an acid-sensitive two-pore domain potassium channel},
  author={H. Meadows and A. Randall},
  • H. Meadows, A. Randall
  • Published 2001
  • Chemistry, Medicine
  • Neuropharmacology
  • Human TASK-3 (hTASK-3) is a recently identified member of the two-pore domain potassium channel (2PDKC) family which in man is predominantly expressed in the cerebellum. Previous preliminary examination of this channel indicates that when expressed in Xenopus oocytes, it produces a K(+) selective background conductance and consequent shift in resting membrane potential, thus mimicking other 2PDKC. Here we describe some additional functional and pharmacological aspects of hTASK-3-mediated… CONTINUE READING
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