Functional characterisation of human SGLT-5 as a novel kidney-specific sodium-dependent sugar transporter.

@article{Grempler2012FunctionalCO,
  title={Functional characterisation of human SGLT-5 as a novel kidney-specific sodium-dependent sugar transporter.},
  author={Rolf Grempler and Robert Augustin and Stefanie Froehner and Tobias Hildebrandt and Eric Simon and Michael R. Van De Mark and Peter Eickelmann},
  journal={FEBS letters},
  year={2012},
  volume={586 3},
  pages={248-53}
}
Sodium glucose cotransporters (SGLT) actively catalyse carbohydrate transport across cellular membranes. Six of the 12 known SGLT family members have the capacity to bind and/or transport monosaccharides (SGLT-1 to 6); of these, all but SGLT-5 have been characterised. Here we demonstrate that human SGLT-5 is exclusively expressed in the kidney. Four splice variants were detected and the most abundant SGLT-5-mRNA was functionally characterised. SGLT-5 mediates sodium-dependent [(14)C]-α-methyl-D… CONTINUE READING