Functional changes of the basal ganglia circuitry in Parkinson's disease

  title={Functional changes of the basal ganglia circuitry in Parkinson's disease},
  author={Fabio Blandini and Giuseppe Nappi and Cristina Tassorelli and Emilia Martignoni},
  journal={Progress in Neurobiology},
The basal ganglia circuitry processes the signals that flow from the cortex, allowing the correct execution of voluntary movements. In Parkinson's disease, the degeneration of dopaminergic neurons of the substantia nigra pars compacta triggers a cascade of functional changes affecting the whole basal ganglia network. The most relevant alterations affect the output nuclei of the circuit, the medial globus pallidus and substantia nigra pars reticulata, which become hyperactive. Such hyperactivity… CONTINUE READING
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