Functional changes during working memory in Huntington’s disease: 30-month longitudinal data from the IMAGE-HD study

@article{Poudel2013FunctionalCD,
  title={Functional changes during working memory in Huntington’s disease: 30-month longitudinal data from the IMAGE-HD study},
  author={Govinda R. Poudel and Julie C. Stout and Juan F Dom{\'i}nguez D and Marcus A. Gray and Louisa Salmon and Andrew J. Churchyard and Phyllis Chua and Beth Borowsky and Gary F. Egan and Nellie Georgiou-Karistianis},
  journal={Brain Structure and Function},
  year={2013},
  volume={220},
  pages={501-512}
}
We characterized 30-month longitudinal change in functional activation and connectivity during working memory in premanifest (pre-HD) and symptomatic (symp-HD) Huntington’s disease (HD). In a case–control longitudinal study (baseline, 18 months, and 30 months), we compared change in fMRI activity over time during working memory in 22 pre-HD, 11 symp-HD, and 20 control participants. Outcome measures were BOLD (blood-oxygen-level-dependent) activity during 1-BACK and 2-BACK working memory and… Expand
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References

SHOWING 1-10 OF 39 REFERENCES
Longitudinal functional magnetic resonance imaging of cognition in preclinical Huntington's disease
TLDR
The present data do not support the notion of a progressive decline of left prefrontal cortex activity in far from onset preHD followed over a 2-year period, and indicate that the activity in brain regions contributing to working memory processing differs consistently in HD expansion mutation carriers while cognitive performance remains normal. Expand
Dorsolateral prefrontal cortex dysfunction in presymptomatic Huntington's disease: evidence from event-related fMRI.
TLDR
It is demonstrated that early functional brain changes in pre-HD subjects may occur in the DLPFC before manifest cortical atrophy, and support a role of this region in the expression of clinical symptoms. Expand
Prefrontal activity in Huntington's disease reflects cognitive and neuropsychiatric disturbances: The IMAGE-HD study
TLDR
It is demonstrated prefrontal response during inhibitory attentional control usefully characterises cognitive and neuropsychiatric status in symp-HD and the functional integrity of compensatory prefrontal responses may provide a useful marker for treatments which aim to sustain cognitive function and delay executive and neuroPsychiatric disturbance. Expand
Cortical dysfunction in patients with Huntington's disease during working memory performance
TLDR
It is found that HD patients were slower and less accurate than healthy controls across all WM load levels, and aberrant cortical function in HD patients may occur in brain regions, which are relatively well preserved in terms of brain atrophy. Expand
fMRI detection of early neural dysfunction in preclinical Huntington's disease
TLDR
FMRI changes in the FAR group occurred in the relative absence of striatal atrophy and behavioral performance deficits, suggesting that fMRI is sensitive to neural dysfunction occurring more than 12 years prior to the estimated onset of manifest HD. Expand
Aberrant connectivity of lateral prefrontal networks in presymptomatic Huntington's disease
TLDR
The results of this study suggest an early frontostriatal and frontoparietal deficit of dissociable functional networks associated with executive processing in pre-HD individuals. Expand
fMRI biomarker of early neuronal dysfunction in presymptomatic Huntington's Disease.
TLDR
Hyperactivation of medial prefrontal regions compensated for reduced subcortical participation during time discrimination in pre-HD, suggesting this pattern of brain activation may represent an early neurobiologic marker of neuronal dysfunction. Expand
Brain activation and functional connectivity in premanifest Huntington's disease during states of intrinsic and phasic alertness
TLDR
The data suggest that while alertness‐related performance remains normal, the underlying frontostriatal activity and motor cortex connectivity decline only when approaching the onset of unequivocal signs of HD. Expand
Biological and clinical changes in premanifest and early stage Huntington's disease in the TRACK-HD study: the 12-month longitudinal analysis
BACKGROUND TRACK-HD is a prospective observational study of Huntington's disease (HD) that examines disease progression in premanifest individuals carrying the mutant HTT gene and those with earlyExpand
Default-mode network connectivity in cognitively unimpaired patients with Parkinson disease
TLDR
The findings revealed a functional disruption of the DMN in cognitively unimpaired patients with PD, in the absence of significant structural differences between patients and controls. Expand
...
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