Functional cardiomyocytes derived from human induced pluripotent stem cells.

@article{Zhang2009FunctionalCD,
  title={Functional cardiomyocytes derived from human induced pluripotent stem cells.},
  author={Jianhua Zhang and Gisela F. Wilson and Andrew Glenn Soerens and Chad H. Koonce and Junying Yu and Sean P Palecek and James A. Thomson and Timothy J Kamp},
  journal={Circulation research},
  year={2009},
  volume={104 4},
  pages={
          e30-41
        }
}
Human induced pluripotent stem (iPS) cells hold great promise for cardiovascular research and therapeutic applications, but the ability of human iPS cells to differentiate into functional cardiomyocytes has not yet been demonstrated. The aim of this study was to characterize the cardiac differentiation potential of human iPS cells generated using OCT4, SOX2, NANOG, and LIN28 transgenes compared to human embryonic stem (ES) cells. The iPS and ES cells were differentiated using the embryoid body… CONTINUE READING

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