Functional cardiac orexin receptors: role of orexin-B/orexin 2 receptor in myocardial protection

@inproceedings{Patel2018FunctionalCO,
  title={Functional cardiac orexin receptors: role of orexin-B/orexin 2 receptor in myocardial protection},
  author={Vanlata H. Patel and Emmanouil Karteris and Jing Chen and Ioannis Kyrou and Harman S. Mattu and Georgios K Dimitriadis and Glenn Christopher. Rodrigo and Charalambos Antoniades and Alexios S Antonopoulos and Bee Kang Tan and Edward W. Hillhouse and Andre Ng and Harpal Randeva},
  booktitle={Clinical science},
  year={2018}
}
Orexins/hypocretins exert cardiovascular effects which are centrally mediated. In the present study, we tested whether orexins and their receptors may also act in an autocrine/paracrine manner in the heart exerting direct effects. Quantitative reverse transcription-PCR (RT-PCR), immunohistochemical and Western blot analyses revealed that the rat heart expresses orexins and orexin receptors (OXR). In isolated rat cardiomyocytes, only orexin-B (OR-B) caused an increase in contractile shortening… CONTINUE READING
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