Functional capacities of human IgM memory B cells in early inflammatory responses and secondary germinal center reactions.

@article{Seifert2015FunctionalCO,
  title={Functional capacities of human IgM memory B cells in early inflammatory responses and secondary germinal center reactions.},
  author={Marc Seifert and Martina Przekopowitz and Sarah Taudien and Anna Lollies and Viola Ronge and Britta Drees and Monika Lindemann and Uwe Hillen and Harald Engler and Bernhard B. Singer and Ralf K{\"u}ppers},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 6},
  pages={E546-55}
}
The generation and functions of human peripheral blood (PB) IgM(+)IgD(+)CD27(+) B lymphocytes with somatically mutated IgV genes are controversially discussed. We determined their differential gene expression to naive B cells and to IgM-only and IgG(+) memory B cells. This analysis revealed a high similarity of IgM(+)(IgD(+))CD27(+) and IgG(+) memory B cells but also pointed at distinct functional capacities of both subsets. In vitro analyses revealed a tendency of activated IgM(+)IgD(+)CD27… CONTINUE READING
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