Functional calcium-sensing receptors in rat fibroblasts are required for activation of SRC kinase and mitogen-activated protein kinase in response to extracellular calcium.

@article{McNeil1998FunctionalCR,
  title={Functional calcium-sensing receptors in rat fibroblasts are required for activation of SRC kinase and mitogen-activated protein kinase in response to extracellular calcium.},
  author={S E McNeil and Susan A. Hobson and Valerie Nipper and Karin D Rodland},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 2},
  pages={
          1114-20
        }
}
Changes in the concentration of extracellular calcium can affect the balance between proliferation and differentiation in several cell types, including keratinocytes, breast epithelial cells, and fibroblasts. This report demonstrates that elevation of extracellular calcium stimulates proliferation-associated signaling pathways in rat fibroblasts and implicates calcium-sensing receptors (CaR) as mediators of this response. Rat-1 fibroblasts express CaR mRNA and protein and respond to known… CONTINUE READING

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