Functional brain mapping by blood oxygenation level-dependent contrast magnetic resonance imaging. A comparison of signal characteristics with a biophysical model.

@article{Ogawa1993FunctionalBM,
  title={Functional brain mapping by blood oxygenation level-dependent contrast magnetic resonance imaging. A comparison of signal characteristics with a biophysical model.},
  author={Seiji Ogawa and Ravi S. Menon and David W. Tank and Shinseog Kim and Hellmut Merkle and Julia Ellermann and Kamil Ugurbil},
  journal={Biophysical journal},
  year={1993},
  volume={64 3},
  pages={803-12}
}
It recently has been demonstrated that magnetic resonance imaging can be used to map changes in brain hemodynamics produced by human mental operations. One method under development relies on blood oxygenation level-dependent (BOLD) contrast: a change in the signal strength of brain water protons produced by the paramagnetic effects of venous blood deoxyhemoglobin. Here we discuss the basic quantitative features of the observed BOLD-based signal changes, including the signal amplitude and its… CONTINUE READING
Highly Influential
This paper has highly influenced 84 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 744 extracted citations

References

Publications referenced by this paper.
Showing 1-2 of 2 references

Functional Brain Mapping by Blood Oxygenation Level - Dependent Contrast Magnetic Resonance Imaging . A Comparison of Signal Characteristics with a Biophysical Model

  • S. Ogawa, R. S. Menon, D. W. Tank, H. Merkle, J. M. Ellermann, K. Ugurbil

Similar Papers

Loading similar papers…