Functional availability of gamma-herpesvirus K-cyclin is regulated by cellular CDK6 and p16INK4a.

@article{Yoshioka2010FunctionalAO,
  title={Functional availability of gamma-herpesvirus K-cyclin is regulated by cellular CDK6 and p16INK4a.},
  author={Hidenori Yoshioka and K. Noguchi and K. Katayama and J. Mitsuhashi and Satoshi Yamagoe and M. Fujimuro and Y. Sugimoto},
  journal={Biochemical and biophysical research communications},
  year={2010},
  volume={394 4},
  pages={
          1000-5
        }
}
  • Hidenori Yoshioka, K. Noguchi, +4 authors Y. Sugimoto
  • Published 2010
  • Biology, Medicine
  • Biochemical and biophysical research communications
  • Viral K-cyclin derived from Kaposi's sarcoma-associated herpesvirus is homologous with mammalian D-type cyclins. Here, we demonstrated the regulatory mechanisms for K-cyclin function and degradation in human embryonic kidney HEK293 and primary effusion lymphoma JSC-1 cell lines. Proteasome inhibitor MG132 treatment induced an accumulation of ubiquitinated K-cyclin in these cells, and co-expression of CDK6 prevented K-cyclin ubiquitination. Also K-cyclin mutants incompetent for CDK6-binding were… CONTINUE READING
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