Functional availability of gamma-herpesvirus K-cyclin is regulated by cellular CDK6 and p16INK4a.

@article{Yoshioka2010FunctionalAO,
  title={Functional availability of gamma-herpesvirus K-cyclin is regulated by cellular CDK6 and p16INK4a.},
  author={Hidenori Yoshioka and Kohji Noguchi and Kazuhiro Katayama and Junko Mitsuhashi and Satoshi Yamagoe and Masahiro Fujimuro and Yoshikazu Sugimoto},
  journal={Biochemical and biophysical research communications},
  year={2010},
  volume={394 4},
  pages={1000-5}
}
Viral K-cyclin derived from Kaposi's sarcoma-associated herpesvirus is homologous with mammalian D-type cyclins. Here, we demonstrated the regulatory mechanisms for K-cyclin function and degradation in human embryonic kidney HEK293 and primary effusion lymphoma JSC-1 cell lines. Proteasome inhibitor MG132 treatment induced an accumulation of ubiquitinated K-cyclin in these cells, and co-expression of CDK6 prevented K-cyclin ubiquitination. Also K-cyclin mutants incompetent for CDK6-binding were… CONTINUE READING

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