Functional association of CTCF with the insulator upstream of the H19 gene is parent of origin-specific and methylation-sensitive

@article{Kanduri2000FunctionalAO,
  title={Functional association of CTCF with the insulator upstream of the H19 gene is parent of origin-specific and methylation-sensitive},
  author={C. Kanduri and V. Pant and D. Loukinov and E. Pugacheva and Chen-Feng Qi and A. Wolffe and R. Ohlsson and Victor V Lobanenkov},
  journal={Current Biology},
  year={2000},
  volume={10},
  pages={853-856}
}
  • C. Kanduri, V. Pant, +5 authors Victor V Lobanenkov
  • Published 2000
  • Biology, Medicine
  • Current Biology
  • In mammals, a subset of genes inherit gametic marks that establish parent of origin-dependent expression patterns in the soma ([1] and references therein). The currently most extensively studied examples of this phenomenon, termed genomic imprinting, are the physically linked Igf2 (insulin-like growth factor II) and H19 genes, which are expressed mono-allelically from opposite parental alleles [1] [2]. The repressed status of the maternal Igf2 allele is due to cis elements that prevent the H19… CONTINUE READING

    Figures and Topics from this paper.

    Chromatin Insulators and CTCF: Architects of Epigenetic States during Development.
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    Role of CTCF Binding Sites in the Igf2/H19 Imprinting Control Region
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    More than insulator: multiple roles of CTCF at the H19-Igf2 imprinted domain
    40
    CpG methylation regulates the Igf2/H19 insulator
    93

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