Functional association of CTCF with the insulator upstream of the H19 gene is parent of origin-specific and methylation-sensitive

@article{Kanduri2000FunctionalAO,
  title={Functional association of CTCF with the insulator upstream of the H19 gene is parent of origin-specific and methylation-sensitive},
  author={Chandrasekhar Kanduri and Vinod Pant and Dmitri I. Loukinov and Elena M. Pugacheva and Chen-Feng Qi and Alan P. Wolffe and Rolf Ohlsson and Victor V. Lobanenkov},
  journal={Current Biology},
  year={2000},
  volume={10},
  pages={853-856}
}
In mammals, a subset of genes inherit gametic marks that establish parent of origin-dependent expression patterns in the soma ([1] and references therein). The currently most extensively studied examples of this phenomenon, termed genomic imprinting, are the physically linked Igf2 (insulin-like growth factor II) and H19 genes, which are expressed mono-allelically from opposite parental alleles [1] [2]. The repressed status of the maternal Igf2 allele is due to cis elements that prevent the H19… CONTINUE READING
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The 5¢-flank of the murine H19 gene in an unusual chromatin conformation unidirectionally blocks enhancerpromoter communication

  • C Kanduri, C Holmgren, M Pilartz, G Franklin, E Ullerås, M Kanduri
  • Curr Biol
  • 2000
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