Functional assessment of the thyrotropin receptor-beta subunit.

  title={Functional assessment of the thyrotropin receptor-beta subunit.},
  author={Ilaria Ciullo and Rauf Latif and Peter F Graves and Terry F Davies},
  volume={144 7},
Posttranslational processing of the TSH receptor (TSHR) involves proteolysis of a single chain holoreceptor into TSHR-alpha (or A) and TSHR-beta (or B) subunits, which remain associated via disulfide bonds and which may then form oligomers. As both uncleaved and cleavage-derived forms of this receptor have been reported to bind TSH and transduce signals, reasons for this cleavage into alpha- and beta-subunits have remained enigmatic. Recently we suggested that TSHR cleavage was related to… CONTINUE READING