Corpus ID: 1230607

Functional assessment of skeletal muscle in mice lacking myostatin by multiparametric functional ( mpf-) NMR in vivo

@inproceedings{Baligand2009FunctionalAO,
  title={Functional assessment of skeletal muscle in mice lacking myostatin by multiparametric functional ( mpf-) NMR in vivo},
  author={C. Baligand and H. Gilson and J. M{\'e}nard and O. Schakman and C. Wary and J. Thissen and P. Carlier},
  year={2009}
}
INTRODUCTION: Myostatin, an endogenous TGF-[beta] growth factor, negatively regulates muscle growth [1]. Deletion of the myostatin gene results in spectacular increase in muscle mass, and has opened the path to therapeutic approaches [2]. Yet improvement in muscle strength does not necessarily match the observed increase in muscle mass [3]. If function is to be preserved in hypertrophic muscle, adequate oxygen supply and substrate utilization should also be maintained. Multiparametric… Expand