Functional assessment of skeletal muscle in intact mice lacking myostatin by concurrent NMR imaging and spectroscopy

@article{Baligand2010FunctionalAO,
  title={Functional assessment of skeletal muscle in intact mice lacking myostatin by concurrent NMR imaging and spectroscopy},
  author={C{\'e}line Baligand and H{\'e}l{\`e}ne Gilson and Jacques C M{\'e}nard and Olivier Schakman and Claire Wary and J. A. Thissen and P G Carlier},
  journal={Gene Therapy},
  year={2010},
  volume={17},
  pages={328-337}
}
Inhibiting myostatin (mstn) causes spectacular increase in muscle mass, spurring research for therapeutic approaches against neuromuscular disorders. Yet, possible functional deterioration and compromised force production have been reported in isolated muscle of null mstn(−/−) mice. We analyzed vascular and metabolic response to repeated electro-stimulated exercise in vivo in mstn−/− mice compared with FVB wild-type controls (WT), using interleaved multi-parametric functional nuclear magnetic… CONTINUE READING
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Muscle perfusion and metabolic function assessed simultaneously and non-invasively in mice, by combined 1H-NMR imaging and 31P-NMR spectroscopy in vivo

  • C Baligand, C Wary, J Menard, D Bertoldi, E Giacomini, PG. Carlier
  • MAGMA
  • 2008

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