Functional assessment in vitro of human-complement-dependent antibody-induced cytotoxicity of neoplastic cells

@article{Brezicka2000FunctionalAI,
  title={Functional assessment in vitro of human-complement-dependent antibody-induced cytotoxicity of neoplastic cells},
  author={Thomas Brezicka and Zakaria Einbeigi and Bengt Bergman},
  journal={Cancer Immunology, Immunotherapy},
  year={2000},
  volume={49},
  pages={235-242}
}
Abstract The complement system is one potential cytotoxic effector mechanism that might be effective in immunotherapy of cancer using monoclonal antibodies (mAb) directed against tumor antigens. In order to evaluate the treatment outcome from trials using mAb in cancer patients, assessment of complement-dependent cytotoxicity (CDC) may therefore be of interest. Here we describe the elaboration of a CDC assay in vitro using a rat hepatoma cell line, H4-II-E, as target cells sensitised with mAb… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 35 REFERENCES

Anti-G(D2) antibody treatment of minimal residual stage 4 neuroblastoma diagnosed at more than 1 year of age.

  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 1998
VIEW 3 EXCERPTS

Adjuvant medical therapy for colorectal cancer.

  • The Surgical clinics of North America
  • 1997
VIEW 1 EXCERPT

Scho®eld PN (1995) Growth factors, cytokines and soluble forms of receptor molecules in cancer patients

W Zumkeller
  • Anticancer Res 15:
  • 1995
VIEW 1 EXCERPT