Functional assessment and structural basis of antibody binding to human papillomavirus capsid.

@article{Zhang2016FunctionalAA,
  title={Functional assessment and structural basis of antibody binding to human papillomavirus capsid.},
  author={Xiao Zhang and Shaowei Li and Yorgo Modis and Zhihai Li and Jun Yu Zhang and Ningshao Xia and Qinjian Rahway Zhao},
  journal={Reviews in medical virology},
  year={2016},
  volume={26 2},
  pages={
          115-28
        }
}
Persistent high-risk human papillomavirus (HPV) infection is linked to cervical cancer. Two prophylactic virus-like particle (VLP)-based vaccines have been marketed globally for nearly a decade. Here, we review the HPV pseudovirion (PsV)-based assays for the functional assessment of the HPV neutralizing antibodies and the structural basis for these clinically relevant epitopes. The PsV-based neutralization assay was developed to evaluate the efficacy of neutralization antibodies in sera… CONTINUE READING
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