Functional assessment and clinical classification of androgen sensitivity in patients with mutations of the androgen receptor gene

@article{Sinnecker1996FunctionalAA,
  title={Functional assessment and clinical classification of androgen sensitivity in patients with mutations of the androgen receptor gene},
  author={G. H. Sinnecker and O. Hiort and E. Nitsche and P. Holterhus and K. Kruse and German Collaborative Intersex Study Group},
  journal={European Journal of Pediatrics},
  year={1996},
  volume={156},
  pages={7-14}
}
  • G. H. Sinnecker, O. Hiort, +3 authors German Collaborative Intersex Study Group
  • Published 1996
  • Medicine
  • European Journal of Pediatrics
  • Abstract In the genetic male, mutations of the androgen receptor (AR) gene cause phenotypes ranging from female to subfertile male. Binding assays on genital skin fibroblasts and DNA analysis alone provide incomplete information about receptor function. We used the sex hormone-binding globulin (SHBG) response to stanozolol as a measure of AR function and correlated the results with phenotypes which were classified according to the degree of defective masculinization. Of the 34 patients… CONTINUE READING
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