Functional apical large conductance, Ca2+-activated, and voltage-dependent K+ channels are required for maintenance of airway surface liquid volume.

@article{Manzanares2011FunctionalAL,
  title={Functional apical large conductance, Ca2+-activated, and voltage-dependent K+ channels are required for maintenance of airway surface liquid volume.},
  author={Dahis Manzanares and Carlos Gonz{\'a}lez and Pedro I Ivonnet and R Chen and Monica Valencia-Gattas and Gregory E. Conner and Hans Peter Larsson and Matthias Salathe},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 22},
  pages={19830-9}
}
Large conductance, Ca(2+)-activated, and voltage-dependent K(+) (BK) channels control a variety of physiological processes in nervous, muscular, and renal epithelial tissues. In bronchial airway epithelia, extracellular ATP-mediated, apical increases in intracellular Ca(2+) are important signals for ion movement through the apical membrane and regulation of water secretion. Although other, mainly basolaterally expressed K(+) channels are recognized as modulators of ion transport in airway… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-2 of 2 references

Importance of Apical BK Channels for Airway Hydration 19838 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

D. Faria, R. Schreiber, K. Kunzelmann
Pflugers Arch. 457, • 2009

Importance of Apical BK Channels for Airway Hydration

M. J. Welsh, P. L. Smith, R. A. Frizzell
J. Membr. Biol • 1983

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