Functional antagonism between c-Jun and MyoD proteins: A direct physical association

@article{Bengal1992FunctionalAB,
  title={Functional antagonism between c-Jun and MyoD proteins: A direct physical association},
  author={E. Bengal and L. Ransone and R. Scharfmann and V. Dwarki and S. Tapscott and H. Weintraub and I. Verma},
  journal={Cell},
  year={1992},
  volume={68},
  pages={507-519}
}
The product of the proto-oncogene Jun inhibits myogenesis. Constitutive expression of Jun in myoblasts interferes with the expression and the function of MyoD protein. In transient transfection assays Jun inhibits transactivation of the MyoD promoter, the muscle creatine kinase enhancer, and a reporter gene linked to MyoD DNA-binding sites. Conversely, MyoD suppresses the transactivation by Jun of genes linked to an AP-1 site. We demonstrate that both in vivo and in vitro MyoD and Jun proteins… Expand
Functional Interaction of Jun and Homeodomain Proteins*
Regulation of c-jun/AP-1 expression in rat L6 myoblasts.
  • G. Thinakaran, J. Bag
  • Biology, Medicine
  • Biochemistry and cell biology = Biochimie et biologie cellulaire
  • 1993
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