Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood

@inproceedings{Davies2012FunctionalAO,
  title={Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood},
  author={Matthew N. Davies and Manuela Volta and Ruth Pidsley and Katie Lunnon and Abhishek Dixit and Simon Lovestone and Cristian Coarfa and R. Alan Harris and Aleksandar Milosavljevic and Claire Troakes and Safa Al-Sarraj and Richard James Butler Dobson and Leonard C. Schalkwyk and Jonathan Mill},
  booktitle={Genome Biology},
  year={2012}
}
Dynamic changes to the epigenome play a critical role in establishing and maintaining cellular phenotype during differentiation, but little is known about the normal methylomic differences that occur between functionally distinct areas of the brain. We characterized intra- and inter-individual methylomic variation across whole blood and multiple regions of the brain from multiple donors. Distinct tissue-specific patterns of DNA methylation were identified, with a highly significant over… CONTINUE READING
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Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood

  • Davies
  • PennCNV. [http://www.openbioinformatics.org…
  • 2012
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