Functional annotation from predicted protein interaction networks

  title={Functional annotation from predicted protein interaction networks},
  author={Jason E. McDermott and Roger Eugene Bumgarner and Ram Samudrala},
  volume={21 15},
MOTIVATION Progress in large-scale experimental determination of protein-protein interaction networks for several organisms has resulted in innovative methods of functional inference based on network connectivity. However, the amount of effort and resources required for the elucidation of experimental protein interaction networks is prohibitive. Previously we, and others, have developed techniques to predict protein interactions for novel genomes using computational methods and data generated… CONTINUE READING


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