Functional and structural properties of ion channels at the nerve terminal depends on compact myelin.

@article{Berret2016FunctionalAS,
  title={Functional and structural properties of ion channels at the nerve terminal depends on compact myelin.},
  author={Emmanuelle Berret and Sei Eun Kim and Seul Lee and Christopher Kushmerick and Jun Hee Kim},
  journal={The Journal of physiology},
  year={2016},
  volume={594 19},
  pages={
          5593-609
        }
}
KEY POINTS In the present study, we document the role of compact myelin in regulating the structural and functional properties of ion channels at the nerve terminals, using electrophysiology, dynamic Na(+) imaging and immunohistochemistry. The subcellular segregation of Na(+) channel expression and intracellular Na(+) dynamics at the heminode and terminal was lost in the dysmyelinated axon from Long-Evans shaker rats, which lack compact myelin. In Long-Evans shaker rats, loss of the Nav β4… CONTINUE READING
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