Functional and structural models of pontine modulation of mechanoreceptor and chemoreceptor reflexes

@article{Song2004FunctionalAS,
  title={Functional and structural models of pontine modulation of mechanoreceptor and chemoreceptor reflexes},
  author={Gang Song and Chi-Sang Poon},
  journal={Respiratory Physiology \& Neurobiology},
  year={2004},
  volume={143},
  pages={281-292}
}
  • G. Song, C. Poon
  • Published 15 November 2004
  • Medicine, Psychology
  • Respiratory Physiology & Neurobiology
The dorsolateral and ventrolateral pons (dl-pons, vl-pons) are critical brainstem structures mediating the plasticity of the Hering-Breuer mechanoreflex (HBR) and carotid chemoreflex (CCR). Review of anatomical evidence indicates that dl-pons and vl-pons are connected reciprocally with one another and with medullary nucleus tractus solitarius (NTS) and ventral respiratory group (VRG). With this structural map, functional models of HBR and CCR are proposed in which the respiratory rhythm is… 
Pontine mechanisms of respiratory control.
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This review focuses on the pontine-mediated inspiratory off-switch (IOS) associated with postinspiratory glottal constriction, which is examined in the context of pontine regulation ofglottal resistance in response to multimodal sensory inputs and higher commands.
Modulation of Hering-Breuer reflex by ventrolateral pons.
TLDR
The inspiratory inhibition and expiratory prolongation effects of the HBR were strengthened after electrical stimulation at the vl-pons but were weakened after microinjecting MK-801.
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It is concluded that neonatal NPB/KF mediated inspiratory off-switch operates on similar synaptic mechanisms as an adult.
Bidirectional plasticity of pontine pneumotaxic postinspiratory drive: implication for a pontomedullary respiratory central pattern generator.
The "pneumotaxic center" in the rostral dorsolateral pons as delineated by Lumsden nine decades ago is known to play an important role in promoting the inspiratory off-switch (IOS) for
Glutamatergic antagonism in the NTS decreases post-inspiratory drive and changes phrenic and sympathetic coupling during chemoreflex activation.
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The data show that glutamatergic neurotransmission in the iNTS and cNTS plays a tonic role on the baseline respiratory rhythm, contributes to the postinspiratory activity, and is essential to expiratory-related sympathoexcitation observed during chemoreflex activation.
Hypoxia-excited neurons in NTS send axonal projections to Kölliker-Fuse/parabrachial complex in dorsolateral pons
TLDR
Findings demonstrate that hypoxia-activated afferent inputs are relayed to the Kölliker-Fuse/parabrachial complex directly via the commissural and medial NTS and indirectly via the ventrolateral NTS subnucleus, VLM and A5 region.
Lateral parabrachial nucleus mediates shortening of expiration during hypoxia
  • G. Song, C. Poon
  • Medicine, Chemistry
    Respiratory Physiology & Neurobiology
  • 2009
TLDR
It is shown that the lateral parabrachial nucleus (LPBN) of the dorsolateral pons specifically mediates T(E)-shortening during hypoxia and not other hypoxic response components.
Cytoarchitecture of Pneumotaxic Integration of Respiratory and Nonrespiratory Information in the Rat
TLDR
The classical definition of the pneumotaxic center is extended to include extensive somatic–axonal–dendritic integration of complex descending and ascending respiratory information as well as nociceptive and possibly musculoskeletal and trigeminal information in multiple dl-pons and vl- pons structures in the rat.
Pontine respiratory activity involved in inspiratory/expiratory phase transition
TLDR
Existing models for ponto-medullary interaction that may be involved in the control of inspiratory duration and IE phase transition are discussed and a number of pontine-Medullary interactions not considered before are proposed.
Respiratory and Mayer wave-related discharge patterns of raphé and pontine neurons change with vagotomy.
TLDR
The results suggest that a distributed network participates in the generation of MWROs and in the coordination of respiratory and vasomotor rhythms.
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