Functional and structural imaging of pain-induced neuroplasticity

@article{Seifert2011FunctionalAS,
  title={Functional and structural imaging of pain-induced neuroplasticity},
  author={Frank Seifert and Christian Maih{\"o}fner},
  journal={Current Opinion in Anaesthesiology},
  year={2011},
  volume={24},
  pages={515–523}
}
Purpose of review The understanding of the mechanisms underlying chronic pain is of major scientific and clinical interest. This review focuses on neuroimaging studies of pain-induced neuroplastic changes in the human brain and discusses five major categories of pain-induced neuroplastic changes. Recent findings First, peripheral or central sensitization may result in increased nociceptive input to the brain and also changes the processing of nociceptive information within the brain. Second… 
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References

SHOWING 1-10 OF 129 REFERENCES
Imaging pain modulation in health and disease
TLDR
Recent findings from functional and anatomical neuroimaging support the notion that an altered interaction of pro and antinociceptive mechanisms may contribute to the development or maintenance of chronic pain states.
Central mechanisms of experimental and chronic neuropathic pain: Findings from functional imaging studies
TLDR
Cerebral processing in experimental pain models, especially those provoking hyperalgesia, and its pharmacological modulation will form the first part of a review of mechanisms of clinical neuropathic pain.
Brain imaging of neuropathic pain
Neuroimaging revolutionizes therapeutic approaches to chronic pain
TLDR
It should now be considered an altered brain state in which there may be altered functional connections or systems and a state that has components of degenerative aspects of the CNS.
Structural Brain Imaging: A Window into Chronic Pain
  • A. May
  • Psychology, Medicine
    The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
  • 2011
TLDR
Any data of an increase or decrease in gray matter in pain syndromes need to be considered in light of all observations gathered in the past 10 years and probably do not justify a discussion of brain damage or consideration of whether the disease is progressive.
Imaging CNS modulation of pain in humans.
TLDR
Recent findings from functional and anatomical neuroimaging support the notion that an altered interaction of pro- and anti-nociceptive mechanisms may contribute to the development or maintenance of chronic pain states.
Brain activity associated with pain, hyperalgesia and allodynia: an ALE meta-analysis
The use of functional brain imaging techniques offers the possibility of uncovering the cerebral processing of the human pain experience. In recent years, many imaging studies have focused on
Brain Gray Matter Decrease in Chronic Pain Is the Consequence and Not the Cause of Pain
TLDR
It is suggested that the gray matter abnormalities found in chronic pain do not reflect brain damage but rather are a reversible consequence of chronic nociceptive transmission, which normalizes when the pain is adequately treated.
Mechanisms of central neuropathic pain: a combined psychophysical and fMRI study in syringomyelia.
TLDR
No significant difference was found in the magnitude or extent of sensory deficits between patients with or without neuropathic pain, suggesting that lesions of the spinothalamic pathways are not sufficient for developing central pain.
...
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