Functional and structural imaging of pain-induced neuroplasticity

@article{Seifert2011FunctionalAS,
  title={Functional and structural imaging of pain-induced neuroplasticity},
  author={Frank Seifert and Christian Maih{\"o}fner},
  journal={Current Opinion in Anaesthesiology},
  year={2011},
  volume={24},
  pages={515–523}
}
Purpose of review The understanding of the mechanisms underlying chronic pain is of major scientific and clinical interest. This review focuses on neuroimaging studies of pain-induced neuroplastic changes in the human brain and discusses five major categories of pain-induced neuroplastic changes. Recent findings First, peripheral or central sensitization may result in increased nociceptive input to the brain and also changes the processing of nociceptive information within the brain. Second… 
View on Wolters Kluwer
ketamineinstitute.com
98 Citations
Highly Influential Citations
1
Background Citations
43
Methods Citations
1

98 Citations

Citation Type

Citation Type

Neurophysiological Principles of Brain Stimulation in Pain Management
TLDR
Evidence indicates that a reversal of maladaptive neuroplastic changes in various chronic pain syndromes is indeed associated with pain relief, and various neuromodulatory approaches can induce enduring alterations of neural activity and connectivity, and therefore can potentially reverse mal Adaptive neuro plastic changes co-occurring with chronic pain.
Pharmacological modulation of brain activity in a preclinical model of osteoarthritis
Neurometabolite Levels and Relevance to Central Sensitization in Chronic Orofacial Pain Patients: A Magnetic Resonance Spectroscopy Study
TLDR
The correlation analysis results suggest that excitatory and inhibitory neurometabolites are involved in the chronification of orofacial pain, including CS.
Characterization of incisional and inflammatory pain in rats using functional tools of MRI
Therapeutic time window of noninvasive brain stimulation for pain treatment: inhibition of maladaptive plasticity with early intervention
TLDR
The authors discuss the potential role of NIBS in blocking maladaptive plasticity using the transition of acute to chronic pain in conditions such as postsurgical pain, central poststroke pain, pain after spinal cord injury and pain after traumatic brain injury as a model.
Decision making in the chronic pain patient (and rodent): Contribution of the orbitofrontal cortex
Surgically Induced Neuropathic Pain: Understanding the Perioperative Process
TLDR
New technologies including direct measures of specific brain function of nociception and new insights into preoperative evaluation of patients including genetic predisposition appear to provide initial opportunities for decreasing the burden of SNPP, until treatments with high efficacy and low adverse effects that either prevent or treat pain are discovered.
Altered evoked low-frequency connectivity from SI to ACC following nerve injury in rats
TLDR
It is shown that both a directed and non-directed connectivity between SI and ACC approach can be used to show the acute changes resulting from the SNI model, likely indicating hypersensitivity of this pathway.
The origins of pain in diverticular disease: peripheral or central?
This study was designed to identify the processes which underlie pain in symptomatic diverticular disease (SDD). Our hypothesis was that a spectrum of both peripheral and central pathologies were…
Distinctive neural responses to pain stimuli during induced sadness in patients with somatoform pain disorder: An fMRI study☆
...
...

References

SHOWING 1-10 OF 129 REFERENCES
Imaging pain modulation in health and disease
TLDR
Recent findings from functional and anatomical neuroimaging support the notion that an altered interaction of pro and antinociceptive mechanisms may contribute to the development or maintenance of chronic pain states.
Central mechanisms of experimental and chronic neuropathic pain: Findings from functional imaging studies
TLDR
Cerebral processing in experimental pain models, especially those provoking hyperalgesia, and its pharmacological modulation will form the first part of a review of mechanisms of clinical neuropathic pain.
Brain imaging of neuropathic pain
Neuroimaging revolutionizes therapeutic approaches to chronic pain
TLDR
It should now be considered an altered brain state in which there may be altered functional connections or systems and a state that has components of degenerative aspects of the CNS.
Structural Brain Imaging: A Window into Chronic Pain
  • A. May
  • Psychology, Medicine
    The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
  • 2011
TLDR
Any data of an increase or decrease in gray matter in pain syndromes need to be considered in light of all observations gathered in the past 10 years and probably do not justify a discussion of brain damage or consideration of whether the disease is progressive.
Imaging CNS modulation of pain in humans.
TLDR
Recent findings from functional and anatomical neuroimaging support the notion that an altered interaction of pro- and anti-nociceptive mechanisms may contribute to the development or maintenance of chronic pain states.
Brain activity associated with pain, hyperalgesia and allodynia: an ALE meta-analysis
The use of functional brain imaging techniques offers the possibility of uncovering the cerebral processing of the human pain experience. In recent years, many imaging studies have focused on…
Brain Gray Matter Decrease in Chronic Pain Is the Consequence and Not the Cause of Pain
TLDR
It is suggested that the gray matter abnormalities found in chronic pain do not reflect brain damage but rather are a reversible consequence of chronic nociceptive transmission, which normalizes when the pain is adequately treated.
Mechanisms of central neuropathic pain: a combined psychophysical and fMRI study in syringomyelia.
TLDR
No significant difference was found in the magnitude or extent of sensory deficits between patients with or without neuropathic pain, suggesting that lesions of the spinothalamic pathways are not sufficient for developing central pain.
An fMRI study of cerebral processing of brush-evoked allodynia in neuropathic pain patients
...
...