Functional and structural conservation in the mechanosensitive channel MscL implicates elements crucial for mechanosensation.

@article{Moe1998FunctionalAS,
  title={Functional and structural conservation in the mechanosensitive channel MscL implicates elements crucial for mechanosensation.},
  author={Paul C. Moe and Paul Blount and Ching Kung},
  journal={Molecular microbiology},
  year={1998},
  volume={28 3},
  pages={583-92}
}
mscL encodes a channel in Escherichia coli that is opened by membrane stretch force, probably serving as an osmotic gauge. Sequences more or less similar to mscL are found in other bacteria, but the degree of conserved function has been unclear. We subcloned and expressed these putative homologues in E. coli and examined their products under patch clamp. Here, we show that each indeed encodes a conserved mechanosensitive channel activity, consistent with the interpretation that this is an… CONTINUE READING

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