Functional and structural characterization of a β-glucosidase involved in saponin metabolism from intestinal bacteria.

@article{Yan2018FunctionalAS,
  title={Functional and structural characterization of a $\beta$-glucosidase involved in saponin metabolism from intestinal bacteria.},
  author={Sha Yan and P. Wei and Q. Chen and X. Chen and Shi-cheng Wang and Jia-ru Li and C. Gao},
  journal={Biochemical and biophysical research communications},
  year={2018},
  volume={496 4},
  pages={
          1349-1356
        }
}
  • Sha Yan, P. Wei, +4 authors C. Gao
  • Published 2018
  • Chemistry, Medicine
  • Biochemical and biophysical research communications
Saponins are natural glycosides widely used in medicine and the food industry. Although saponin metabolism in human is dependent on intestinal microbes, few involving bacteria enzymes have been identified. We cloned BlBG3, a GH3 β-glucosidase from Bifidobacterium longum, from human stool. We found that BlBG3 catalyzes the hydrolysis of glycoside furostanol and ginsenoside Rb1 at higher efficiency than other microbial β-glucosidases. Structural analysis of BlBG3 in complex with d-glucose… Expand
Biocatalytic strategies for the production of ginsenosides using glycosidase: current state and perspectives
  • Wei-Na Li, D. Fan
  • Chemistry, Medicine
  • Applied Microbiology and Biotechnology
  • 2020
[Biocatalytic strategies in producing ginsenoside by glycosidase-a review].
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