Functional and regulatory interactions between Hox and extradenticle genes.

  title={Functional and regulatory interactions between Hox and extradenticle genes.},
  author={Natalia Azpiazu and Gin{\'e}s Morata},
  journal={Genes & development},
  volume={12 2},
The homeobox gene extradenticle (exd) acts as a cofactor of Hox function both in Drosophila and vertebrates. It has been shown that the distribution of the Exd protein is developmentally regulated at the post-translational level; in the regions where exd is not functional Exd is present only in the cell cytoplasm, whereas it accumulates in the nuclei of cells requiring exd function. We show that the subcellular localization of Exd is regulated by the BX-C genes and that each BX-C gene can… CONTINUE READING


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Functional dissection of Ultrabithorax proteins in Drosophila melanogaster

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