Functional and physical interaction of protein-tyrosine kinases Fyn and Csk in the T-cell signaling system.

@article{Takeuchi1993FunctionalAP,
  title={Functional and physical interaction of protein-tyrosine kinases Fyn and Csk in the T-cell signaling system.},
  author={Masaru Takeuchi and Satomi Kuramochi and Noemi Fusaki and S. Nada and Junko Kawamura-Tsuzuku and Satoshi Matsuda and Kentaro Semba and Kyoko Toyoshima and Masato Okada and Tetsuya Yamamoto},
  journal={The Journal of biological chemistry},
  year={1993},
  volume={268 36},
  pages={27413-9}
}
The Src-like protein-tyrosine kinase Fyn is associated with T-cell antigen receptor. Transient expression of actively mutated Fyn, having Phe-528 instead of Tyr-528 or Thr-338 instead of Ile-338, in Jurkat T-cells stimulated the serum response element (SRE), 12-O-tetradecanoyl-phorbol-13-acetate response element, cyclic AMP response element, and c-fos promoter. The stimulation of SRE was particularly prominent not only with active Fyn but also with normal (wild-type) Fyn. SRE was also… CONTINUE READING
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