Functional and phenotypic differences between glioblastoma multiforme-derived and normal human brain endothelial cells.

@article{Charalambous2005FunctionalAP,
  title={Functional and phenotypic differences between glioblastoma multiforme-derived and normal human brain endothelial cells.},
  author={Christiana Charalambous and Florence M. Hofman and Thomas C. Chen},
  journal={Journal of neurosurgery},
  year={2005},
  volume={102 4},
  pages={699-705}
}
OBJECT Glioblastomas multiforme (GBMs) are hypervascular tumors characterized by endothelial cell (EC) proliferation. There is increasing evidence that ECs that infiltrate systemic tumors are different from normal blood vessel cells; whether this difference is seen in the central nervous system between GBM and normal brain tissue is not known. The goal of this investigation was to characterize and compare the functional and phenotypic properties of GBM-associated ECs and normal brain ECs… CONTINUE READING

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