Functional and pharmacological properties of canine ERG potassium channels.

  title={Functional and pharmacological properties of canine ERG potassium channels.},
  author={Jixin Wang and Kristian Penna and Hao Wang and Jerzy Karczewski and Thomas M. Connolly and Kenneth S. Koblan and Paul B. Bennett and Joseph J. Salata},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={284 1},
We established HEK-293 cell lines that stably express functional canine ether-à-go-go-related gene (cERG) K(+) channels and examined their biophysical and pharmacological properties with whole cell patch clamp and (35)S-labeled MK-499 ([(35)S]MK-499) binding displacement. Functionally, cERG current had the hallmarks of cardiac delayed rectifier K(+) current (I(Kr)). Channel opening was time- and voltage dependent with threshold near -40 mV. The half-maximum activation voltage was -7.8 +/- 2.4… CONTINUE READING
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