Functional and non-functional nerve-smooth muscle transmission in the renal arteries of the newborn and adult rabbit and guinea-pig.

@article{Gallen1982FunctionalAN,
  title={Functional and non-functional nerve-smooth muscle transmission in the renal arteries of the newborn and adult rabbit and guinea-pig.},
  author={D D Gallen and Timothy Cowen and S G Griffith and Aldwyn J Haven and Geoffrey Burnstock},
  journal={Blood vessels},
  year={1982},
  volume={19 5},
  pages={237-46}
}
Isolated renal arteries from newborn and adult guinea-pigs failed to respond to electrical stimulation of the intramural nerves, using parameters identical to those which elicit large neurogenic contractions in renal arteries from newborn and adult rabbits. The threshold stimulation frequency was lower and responses were greater in adult compared with neonatal rabbits. Comparisons of noradrenaline EC50 values showed that guinea-pig renal arteries are significantly less sensitive to… CONTINUE READING