Functional and morphological study of retinal photoreceptor cell degeneration in transgenic rabbits with a Pro347Leu rhodopsin mutation

  title={Functional and morphological study of retinal photoreceptor cell degeneration in transgenic rabbits with a Pro347Leu rhodopsin mutation},
  author={K. Asakawa and H. Ishikawa and S. Uga and K. Mashimo and K. Shimizu and M. Kondo and H. Terasaki},
  journal={Japanese Journal of Ophthalmology},
PurposeTo investigate the process of retinal degeneration by analyzing the functional and morphological findings in transgenic rabbits with a Pro347Leu rhodopsin mutation.MethodsWild-type (WT) and transgenic (Tg) rabbits at ages 4, 8 and 12 months were used. We conducted functional evaluation by recording the changes in the pupil response to red and blue light stimulation and the amplitude of the electroretinography (ERG). Morphologically, rod and cone distribution was examined using light and… Expand
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Rabbits have large eyes and are easy to handle and breed, they will provide a useful animal model for the study of the pathophysiology of and new treatments for retinal degeneration, and this is the first rabbit model of progressive retina degeneration. Expand
Focal cone ERGs of rhodopsin Pro347Leu transgenic rabbits
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Supernormal ERG oscillatory potentials in transgenic rabbit with rhodopsin P347L mutation and retinal degeneration.
The greater effect of TTX on the OP amplitudes in Tg rabbits suggests that the supernormal OPs in TG rabbits may be related to secondary changes in the spiking neurons of the inner retina after photoreceptor degeneration. Expand
Pharmacological dissection of multifocal electroretinograms of rabbits with Pro347Leu rhodopsin mutation
The ON-bipolar cell and inner retinal responses were altered at the early stage ofPhotoreceptor degeneration in Tg rabbits despite the preservation of the cone photoreceptor responses. Expand
P23H rhodopsin transgenic rat: correlation of retinal function with histopathology.
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Transcorneal electrical stimulation promotes survival of photoreceptors and improves retinal function in rhodopsin P347L transgenic rabbits.
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Enhancement of ON-bipolar cell responses of cone electroretinograms in rabbits with the Pro347Leu rhodopsin mutation.
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Altered light responses of single rod photoreceptors in transgenic pigs expressing P347L or P347S rhodopsin.
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