Functional and morphological study of retinal photoreceptor cell degeneration in transgenic rabbits with a Pro347Leu rhodopsin mutation

@article{Asakawa2015FunctionalAM,
  title={Functional and morphological study of retinal photoreceptor cell degeneration in transgenic rabbits with a Pro347Leu rhodopsin mutation},
  author={K. Asakawa and H. Ishikawa and S. Uga and K. Mashimo and K. Shimizu and M. Kondo and H. Terasaki},
  journal={Japanese Journal of Ophthalmology},
  year={2015},
  volume={59},
  pages={353-363}
}
PurposeTo investigate the process of retinal degeneration by analyzing the functional and morphological findings in transgenic rabbits with a Pro347Leu rhodopsin mutation.MethodsWild-type (WT) and transgenic (Tg) rabbits at ages 4, 8 and 12 months were used. We conducted functional evaluation by recording the changes in the pupil response to red and blue light stimulation and the amplitude of the electroretinography (ERG). Morphologically, rod and cone distribution was examined using light and… Expand
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