Functional and morphological modifications of the urinary bladder in aging female rats.

  title={Functional and morphological modifications of the urinary bladder in aging female rats.},
  author={Philippe Lluel and Stefano Palea and Martin Barras and F Grandadam and Didier Heudes and Patrick Bruneval and Bruno Corman and D. J. Martin},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  volume={278 4},
  • P. LluelS. Palea D. Martin
  • Published 1 April 2000
  • Biology, Medicine
  • American journal of physiology. Regulatory, integrative and comparative physiology
In female Wistar/Rij rats, 10 and 30 mo old, the micturition profiles in conscious animals, the contractile responses of the isolated urinary bladder, and the histology of the vesical tissue have been investigated. During cystomanometry, 60% of conscious senescent rats, but only 25% of young adult rats, showed spontaneous contractions during the bladder-filling phase. In aging rats, micturition pressure and duration of micturition were significantly higher by approximately 40-50%. In contrast… 

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