Functional and morphological effects of grape seed proanthocyanidins on peripheral neuropathy in rats with type 2 diabetes mellitus.

@article{Ding2014FunctionalAM,
  title={Functional and morphological effects of grape seed proanthocyanidins on peripheral neuropathy in rats with type 2 diabetes mellitus.},
  author={Ye Ding and Xiaoqian Dai and Yanfei Jiang and Zhaofeng Zhang and Yong Li},
  journal={Phytotherapy research : PTR},
  year={2014},
  volume={28 7},
  pages={1082-7}
}
Grape seed proanthocyanidins (GSPs) possess a broad spectrum of pharmacological and therapeutic properties. The aim of this study was to examine the effect of GSPs on functional and morphological abnormalities in the peripheral nerves of rats with type 2 diabetes mellitus. Diabetic rats were induced by two injections of 25 mg streptozotocin/kg body weight and 8 weeks of a high-carbohydrate/high-fat diet. GSPs were then administrated to the rats for 16 weeks. Thermal and mechanical sensitivity… CONTINUE READING
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