Functional and morphological characteristics of the retinal and choroidal vasculature

  title={Functional and morphological characteristics of the retinal and choroidal vasculature},
  author={Dao-Yi Yu and Paula K. Yu and Stephen J. Cringle and Min Hye Kang and E-N. Su},
  journal={Progress in Retinal and Eye Research},
  • Dao-Yi Yu, P. Yu, E. Su
  • Published 1 May 2014
  • Medicine, Biology
  • Progress in Retinal and Eye Research
Association of systemic cardio-vasculature status with retinal vascular endothelium in diabetes
Altered blood flow in the central retinal vein in the postlaminar region has been detected in patients who experience progression of diabetic retinopathy and may play a major role in the pathogenetic mechanism that has often been overlooked.
Nutrition and Vascular Supply of Retinal Ganglion Cells during Human Development
This delicately balanced situation of RGC nutrition is described in the different regions of the eye, and a new graphic presentation is introduced to combine morphological measurements and clinical visual field data.
Microvascular Network and Its Endothelial Cells in the Human Iris
The human iris vasculature was found to comprise of six orders of arteries, three orders of veins, and capillaries, and the endothelial cell shape was long and narrow in all arteries, suggesting a high hemodynamic shear stress.
Retinal capillary perfusion: Spatial and temporal heterogeneity
Quantitative study of the microvasculature and its endothelial cells in the porcine iris.
The Role of Retinal Venous Congestion in Diabetic Retinopathy
Data is presented from studies that investigated ocular blood flow and ocular morphology that suggest involvement of retinal vein congestion in the pathogenesis of DR and evidence suggests an involvement ofretinal venous congestion in DR.
Angiogenesis and Eye Disease.
The lessons learned from the study of retinal vascular development are focused on and how these lessons can be used to better maintain adult vascular networks and prevent retinal diseases.
Inter-Relationship of Arterial Supply to Human Retina, Choroid, and Optic Nerve Head Using Micro Perfusion and Labeling.
The results indicate an inter-relationship of arterial supply to the retina, choroid, and ONH in the human eye, which has important implications in understanding clinical observations and disease mechanisms such as that of glaucoma and ischemic optic nerve disease.
Three-Dimensional Characterization of the Normal Human Parafoveal Microvasculature Using Structural Criteria and High-Resolution Confocal Microscopy
Structural criteria gathered using confocal microscopy were used to reconcile the three-dimensional organization and connectivity of the parafoveal microvasculature and may help to develop an understanding of the pattern of retinal lesions characterizing a myriad of Retinal vascular diseases.


Heterogeneous endothelial cell structure along the porcine retinal microvasculature.
The structural heterogeneity of endothelial cells along the pig retinal circulation suggests that functional heterogeneity of the endothelium may be involved in regulation of retinal blood flow.
Role of the retinal vascular endothelial cell in ocular disease
Alterations to vascular endothelium in the optic nerve head in patients with vascular comorbidities.
Morphometric characteristics of central retinal artery and vein endothelium in the normal human optic nerve head.
Arterial-like appearance of venous endothelium in the posterior lamina cribrosa, where pressure gradient forces are predicted to be greatest and CRV luminal diameter is known to be narrowest, implicates this as a site of altered hemodynamic stress.
The structural relationship between the microvasculature, neurons, and glia in the human retina.
A microperfusion fixation and staining technique has been developed that allows studies of the structural relationships of vascular, glial, and neuronal elements at the cellular level in human donor eyes.
Cellular mechanisms of blood-retinal barrier dysfunction in macular edema
BRB dysfunction may be mediated by leakage through the tight junctions of RVE or RPE cells, by trans-endothelial vesicular transport, or by permeation of Rve or R PE cells that have undergone degenerative changes.
The multifunctional choroid