Functional and molecular characterization of a T-type Ca(2+) channel during fetal and postnatal rat heart development.

@article{Ferron2002FunctionalAM,
  title={Functional and molecular characterization of a T-type Ca(2+) channel during fetal and postnatal rat heart development.},
  author={Laurent Ferron and V{\'e}ronique Capuano and Edith Deroubaix and Alain Coulombe and Jean-François Renaud},
  journal={Journal of molecular and cellular cardiology},
  year={2002},
  volume={34 5},
  pages={533-46}
}
T-type calcium current (I(CaT)) is distributed among a large variety of species and tissues. The main functions of I(CaT) are thought to be related to pacemaker activity and to the cell cycle. Using the whole-cell patch-clamp configuration, we showed that fetal rat ventricular cells exhibit an I(CaT) with electrophysiological and pharmacological characteristics similar to those already described for this current. We investigated I(CaT) density and found that this current was mainly expressed in… CONTINUE READING