Functional and molecular analyses of 10q deletions in human gliomas.

@article{Steck1999FunctionalAM,
  title={Functional and molecular analyses of 10q deletions in human gliomas.},
  author={Peter A. Steck and Huai Lin and Lauren A. Langford and Samar A. Jasser and Dimpy Koul and W. K. Alfred Yung and Mark A. Pershouse},
  journal={Genes, chromosomes & cancer},
  year={1999},
  volume={24 2},
  pages={135-43}
}
Extensive genomic deletions involving chromosome 10 are the most common genetic alteration in glioblastoma multiforme (GBM). To localize and examine the potential roles of two chromosome arm 10q tumor suppressor regions, we used two independent strategies: mapping of allelic deletions, and functional analysis of phenotypic suppression after transfer of… CONTINUE READING