Functional and immunohistochemical characterization of CB1 and CB2 receptors in rat bladder.

@article{Hayn2008FunctionalAI,
  title={Functional and immunohistochemical characterization of CB1 and CB2 receptors in rat bladder.},
  author={Matthew H. Hayn and Inmaculada Ballesteros and Fernando de Miguel and Christian H. Coyle and Shachi Tyagi and Naoki Yoshimura and Michael B Chancellor and Pradeep Tyagi},
  journal={Urology},
  year={2008},
  volume={72 5},
  pages={1174-8}
}
OBJECTIVES To determined the localization of CB(1) and CB(2) receptors in rat bladder and investigate the effect of a mixed CB(1)/CB(2) receptor agonist, ajulemic acid (AJA), on chemically evoked release of the sensory neuropeptide calcitonin gene-related peptide (CGRP). METHODS Whole rat bladders were incubated in a series of tissue baths containing physiologic salt solution to measure baseline CGRP release by enzyme immunoassay. Capsaicin (30 nM) and adenosine triphosphate (10 muM) were… CONTINUE READING