Functional and histological evidence for the protective effect of NXY-059 in a primate model of stroke when given 4 hours after occlusion.

@article{Marshall2003FunctionalAH,
  title={Functional and histological evidence for the protective effect of NXY-059 in a primate model of stroke when given 4 hours after occlusion.},
  author={Jonathan W B Marshall and Rosalyn M Cummings and Laura J Bowes and Rosalind M. Ridley and Alfred Richard Green},
  journal={Stroke},
  year={2003},
  volume={34 9},
  pages={2228-33}
}
BACKGROUND AND PURPOSE NXY-059 has substantial protective effects when administered immediately after the onset of ischemia in a primate model of stroke. This study examined the efficacy of this drug when administered 4 hours after onset, a more clinically relevant time point. METHODS Before surgery, marmosets were trained and tested on a number of neurological tests, which assessed general neurological function, motor ability, and spatial awareness. Four hours after permanent middle cerebral… CONTINUE READING
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Comparison of neuroprotective data for NXY-059 in animal models with the STAIR criteria

  • KR Lees, AR Green, T. Odergren
  • Cerebrovasc Dis. 2001;11(suppl 4):77
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