Functional and genetic diversity of leukocyte immunoglobulin-like receptor and implication for disease associations

Human leukocyte immunoglobulin-like receptors (LILR) are a family of 11 functional genes encoding five activating (LILRA1, 2, 4–6), five inhibitory (LILRB1–5) and one soluble (LILRA3) form. The number of LILR genes is conserved among individuals, except for LILRA3 and LILRA6, which exhibit copy-number variations. The LILR genes are rapidly evolving and… CONTINUE READING