Functional and genetic analysis of two CD8 T cell subsets defined by the level of CD45RC expression in the rat.

@article{Xystrakis2004FunctionalAG,
  title={Functional and genetic analysis of two CD8 T cell subsets defined by the level of CD45RC expression in the rat.},
  author={Emmanuel Xystrakis and Pierre Cavailles and Anne S. Dejean and Bastien Cautain and C{\'e}line Colacios and Dominique Lagrange and Marie-Jose van de Gaar and Isabelle Bernard and Daniel Gonzalez-Dunia and Jan Damoiseaux and Gilbert Jean Fourni{\'e} and Abdelhadi Saoudi},
  journal={Journal of immunology},
  year={2004},
  volume={173 5},
  pages={3140-7}
}
Differential cytokine production by T cells plays an important role in the outcome of the immune response. We show that the level of CD45RC expression differentiates rat CD8 T cells in two subpopulations, CD45RC(high) and CD45RC(low), that have different cytokine profiles and functions. Upon in vitro stimulation, in an Ag-presenting cell-independent system, CD45RC(high) CD8 T cells produce IL-2 and IFN-gamma while CD45RC(low) CD8 T cells produce IL-4, IL-10, and IL-13. In vitro, these subsets… CONTINUE READING
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