Functional and genetic analysis in type 2 diabetes of Liver X receptor alleles – a cohort study

  title={Functional and genetic analysis in type 2 diabetes of Liver X receptor alleles – a cohort study},
  author={Ingrid Dahlman and Maria M Nilsson and Harvest F Gu and Cecile Lecoeur and Suad Efend{\'i}c and Claes-G{\"o}ran {\"O}stenson and Kerstin E Brismar and Jan-{\AA}ke Gustafsson and Philippe Froguel and Martine Vaxillaire and Karin Dahlman-Wright and Knut R. Steffensen},
  journal={BMC Medical Genetics},
  pages={27 - 27}
Liver X receptor alpha (LXRA) and beta (LXRB) regulate glucose and lipid homeostasis in model systems but their importance in human physiology is poorly understood. This project aimed to determine whether common genetic variations in LXRA and LXRB associate with type 2 diabetes (T2D) and quantitative measures of glucose homeostasis, and, if so, reveal the underlying mechanisms. Eight common single nucleotide polymorphisms in LXRA and LXRB were analyzed for association with T2D in one French… CONTINUE READING
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