Functional and fine structural characteristics of the sensory neuron blocking effect of capsaicin

  title={Functional and fine structural characteristics of the sensory neuron blocking effect of capsaicin},
  author={János Szolcsányi and Aurelia Jancs{\'o}-G{\'a}bor and F. Jo{\'o}},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
SummaryIn the eye of rats the long-lasting specific desensitization induced by local or systemic capsaicin treatment is characterized by three phases: 1. complete insensitivity, 2. decreased sensitivity and a tendency to rapid adaptation, 3. normal initial sensitivity with a tendency to rapid adaptation to chemical pain stimuli. A low density of microvesicles and swollen mitochondria were found after local capsaicin treatment in certain nerve endings of the cornea of rats, but no signs of… 

Direct evidence for an axonal site of action of capsaicin

It is suggested that local capsaicin treatment of peripheral nerves selectively damages the chemosensitive nerve fibres presumably by depleting their substance P content.

Time course of capsaicin-induced functional impairments in comparison with changes in neuronal substance P content

Neurogenic plasma extravasation and the chemosensitivity of the cornea were greatly diminished already 10 min after systemic capsaicin treatment, and are therefore caused by actions other than depletion of substance P.

The Mysteries of Capsaicin-Sensitive Afferents

The long sought-after capsaicin receptor, now known as TRPV1 (transient receptor potential cation channel, subfamily V member 1), was cloned more than two decades ago and several “mysteries” remain unsolved, including the molecular underpinnings of “capsaicin desensitization,” and the exact role these nerves play in thermoregulation and heat sensation.

Capsaicin and sensory neurones: a historical perspective.

  • J. Szolcsányi
  • Biology
    Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques
  • 2014
This introductory chapter outlines the historical background based on the author's 50 years of experience in this field and emphasizes new scopes, fascinating perspectives in pharmaco-physiology, and molecular pharmacology of nociceptive sensory neurons for pain relief in persistent pathological pain states.

Changes in features of degenerating primary sensory neurons with time after capsaicin treatment

Interestingly, capsaicin seemed to have both a direct and indirect action on DRG neurons: its direct action induced rapid degeneration of the smaller neurons, whereas its indirect action induced relatively slow degeneration in the larger neurons, causing chromatolytic changes similar to those induced by periphal nerve axotomy.

Vanilloid-Induced Conduction Analgesia: Selective, Dose-Dependent, Long-Lasting, with a Low Level of Potential Neurotoxicity

Data indicate possible clinical applicability of vanilloid-induced conduction analgesia, and the frequency of unmyelinated fiber degeneration was more than an order of magnitude lower than that with the therapeutic concentration of lidocaine.

Differential effects of capsaicin on the content of somatostatin, substance P, and neurotensin in the nervous system of the rat

These experiments show that capsaicin treatment of rats caused a depletion of both I-SRIF and I-SP in primary sensory neurons, which suggests that depletion of the entire neuron requires an action of Capsaicin on the peripheral branch and/or the cell body.



Effects of colchicine, vinblastine and vincristine on degeneration transmitter release after sympathetic denervation studied in the conscious rat.

It is proposed that the drugs postpone the degeneration transmitter release by slowing down the rate by which an “axotomy information” is transported distally along the neuron.

Direct evidence for neurogenic inflammation and its prevention by denervation and by pretreatment with capsaicin.

The question of the role played by the sensory nerves in the mechanism of the inflammatory response arose at the beginning of this century and was almost entirely neglected in modem research and experimental work has been confined mainly to the study of axon reflex flare in human skin.

Ultrastructural changes in the rat superior cervical ganglion following prolonged guanethidine administration.

The structural changes observed following prolonged administration of guanethidine may induce metabolic alterations of the sympathetic ganglion cells impeding the function of the postganglionic neurone without affecting the ganglionic transmission or the survival of the gangLion cells.

Mitochondrial Changes in Preoptic Neurones after Capsaicin Desensitization of the Hypothalamic Thermodetectors in Rats

CAPSAICIN, the pungent principle in red pepper (paprika), is a potent irritant causing a sensation of burning pain. After initial violent stimulation, however, this substance induces a selective

Decline of Tissue Noradrenaline under the Influence of a Mitotic Inhibitor

Vinblastine, a mitotic inhibitor used in the treatment of certain cancers, affects formation of neurotubules, and it is injected intravenously into rats in an attempt to interfere with the intra-axonal transport of noradrenaline in sympathetic nerves generally.

Studies on the translocation of noradrenaline‐containing vesicles in post‐ganglionic sympathetic neurones in vitro. Inhibition of movement by colchicine and vinblastine and evidence for the involvement of axonal microtubules

1. Methods are presented for studying axonal transport mechanisms in preparations of constricted hypogastric nerve/inferior mesenteric ganglia maintained in vitro for periods up to 48 hr. Under these

Reaction of Corneal Nerve Fibres to Injury *

A study of degeneration and regeneration of nerve fibres in this tissue provides other data of considerable interest, and a number of experimental procedures designed to test the validity of observations made by the direct method are described.


  • S. Ochs
  • Biology
    Annals of the New York Academy of Sciences
  • 1974
In this review the linearly organized internal systems of transport present in the nerve fiber are emphasized. These systems carry materials down the axon needed to maintain its excitability,

The effects of nerve stimulation and hemicholinium on synaptic vesicles at the mammalian neuromuscular junction

Electron micrographs of nerve terminals in rat phrenic nerve—diaphragm preparations have been studied and the effectiveness of nerve stimulation has been monitored by intracellular micro‐electrode recordings from the muscle cells.