Functional and energetic characterization of P-gp-mediated doxorubicin transport in rainbow trout (Oncorhynchus mykiss) hepatocytes.

@article{Hildebrand2009FunctionalAE,
  title={Functional and energetic characterization of P-gp-mediated doxorubicin transport in rainbow trout (Oncorhynchus mykiss) hepatocytes.},
  author={Jennifer L Hildebrand and Onkar S. Bains and Denny S H Lee and Christopher R. J. Kennedy},
  journal={Comparative biochemistry and physiology. Toxicology & pharmacology : CBP},
  year={2009},
  volume={149 1},
  pages={65-72}
}
An assessment of energetic costs associated with P-glycoprotein (P-gp)-mediated xenobiotic efflux is important in understanding the energy budgets, tradeoffs, and fitness of organisms inhabiting contaminated environments. Here, a functional characterization and determination of the energetic costs associated with doxorubicin (DOX) efflux was examined in isolated hepatocytes of rainbow trout. The accumulation and efflux of DOX were both concentration dependent. The efflux of DOX over a 3 h… CONTINUE READING