Functional and cardioprotective effects of simultaneous and individual activation of protein kinase A and Epac

@inproceedings{Khaliulin2017FunctionalAC,
  title={Functional and cardioprotective effects of simultaneous and individual activation of protein kinase A and Epac},
  author={Igor Khaliulin and Mark Bond and Andrew F James and Zara Dyar and Raheleh Amini and Jason L Johnson and M Suleiman},
  booktitle={British journal of pharmacology},
  year={2017}
}
BACKGROUND AND PURPOSE Myocardial cAMP elevation confers cardioprotection against ischaemia/reperfusion (I/R) injury. cAMP activates two independent signalling pathways, PKA and Epac. This study investigated the cardiac effects of activating PKA and/or Epac and their involvement in cardioprotection against I/R. EXPERIMENTAL APPROACH Hearts from male rats were used either for determination of PKA and PKC activation or perfused in the Langendorff mode for either cardiomyocyte isolation or used… CONTINUE READING
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