Functional and biochemical characterization of osteoclast-like cells derived from giant cell tumours of bone.

Abstract

Cells harvested from human giant cell tumours of bone were characterized on the basis of morphological features, proliferative capacity, total(AP) and tartrate resistant acid phosphatase (TRAP) activity, and hormonal response. Culture were formed by mononucleated and multinucleated cells. Mononucleated cells showed fibroblastic morphology, whereas multinucleated cells showed osteoclastic phenotype. We conclude that in these cultures mature osteoclasts and their mononuclear precursors are present.

Cite this paper

@article{Grano1992FunctionalAB, title={Functional and biochemical characterization of osteoclast-like cells derived from giant cell tumours of bone.}, author={Maria Grano and Sylvia Colucci and A J Portoghese and G. Zambonin and Raniero Barattolo and Massimo Serra and Katia Scotlandi and Anna Maria Teti and A Z Zambonin Zallone}, journal={Bollettino della Società italiana di biologia sperimentale}, year={1992}, volume={68 4}, pages={249-53} }