Functional and Serological Evidences of the Non-Immune Interaction of Interleukin-2 and Immunoglobulin G.

@article{Sobolev2000FunctionalAS,
  title={Functional and Serological Evidences of the Non-Immune Interaction of Interleukin-2 and Immunoglobulin G.},
  author={Stanislav M. Sobolev and A V Pronin},
  journal={Russian journal of immunology : RJI : official journal of Russian Society of Immunology},
  year={2000},
  volume={5 2},
  pages={203-208}
}
The mechanism of non-immune inhibition of biological activity of IL-2 by IgG or its immune complexes was studied using serological analysis on the model of IL-2-dependent proliferation of Con A-induced blast cells obtained from a mouse spleen. The mechanism investigated is realized through formation of a complex between IL-2 and an effector part of IgG molecule. It is suggested that this mechanism can participate in immune regulation, formation of individual and population resistance to… CONTINUE READING